ea0041gp28 | Adrenal (2) | ECE2016
Debono Miguel
, Harrison Robert
, Chadarevian Rita
, Gueroult Carole
, Abitbol Jean-Louis
, Newell-Price John
Introduction: Patients with adrenal incidentalomas and sub-clinical Cushings (SCH) have increased cardiovascular events and mortality. We hypothesised that these patients have a disturbed cortisol rhythm amenable to being restored to normal by using timed short-acting cortisol synthesis blockade, and that this may have a positive effect on IL6 levels.Methods: In a phase 1, prospective study (Eudract No. 2012-002586-35) we recruited eight patients w...